Genesis of Research and Personalized Medicine Concepts

While working on the dynamics of logic and emotion in decision making and the cognitive processes associated with change inertia, the efforts of the members of The Center led them into the study of neurohormones (brain chemicals).

During this process, one of The Center's members identified unique corollary relationships between neurohormones. Intrigued by the apparent patterns, the team researched scientific literature and identified a cascade of hormones that emanate from the brain (hypothalamus). The patterns of correlation were again apparent.

The team added a research biologist and formed a separate Life Sciences group to investigate the scientific literature to determine if the patterns would also apply to genes (proteins). The group's research confirmed that the patterns remained consistent. The group then called upon advisors from chemistry and physics to see if the pattern would also apply in physical sciences.

To the amazement of the newly formed Life Sciences group, it became apparent that these patterns of corollary relationships (the "model") could be applied to scientific processes for maintaining equilibrium (balance or homeostasis) throughout all of science; from subatomic particles to chemistry as well as between the body's substances.

While the global research community knows that homeostasis exists, the fact that a mechanism has not existed for evaluating homeostatic relationships between the body's substances can be validated by anyone familiar with medical research. For clarification, by definition, homeostasis is the state of balance that, practically speaking, provides "wellness." To have balance, a mutualistic relationship must exist between substances.

Until The Center's discovery, the tacit knowledge of the dynamics of homeostasis in the body had never been converted into an explicit, replicable model. The Center has identified precisely that explicit process.

Applying The Center's model to medical research

With the initiation of the Human Genome Project, the global scientific community focused on ontological studies and other genomic research methods in pursuit of causal paths for illnesses and disease entities. These efforts placed the emphasis of research onto the body's foundational substances (i.e. chromosomes, DNA and RNA).

During this period, however, evidence-based medicine still provided the knowledge that disruptions in hormones, proteins, peptides, enzymes, lipids, bacteria, and other compositional substances in the body are the sources of most illnesses and disease entities. The Center's model for assessing homeostasis of these substances is explained in the tutorial provided in the section of the web site; Model for Homeostasis. 

In addition to the model for assessing homeostasis in the body's substances, the Life Sciences group has developed other tools for use by the community of research scientists in order to enhance the integration of knowledge between multiple diverse disciplines. These models, based on complexity science-like processes, are available to academic research centers without fees or remuneration through partnerships with The Center as well as for license to proprietary organizations.

Specific questions or inquiries regarding the work of The Center's Life Sciences group should be directed to Linda Oliver Perrier at loliverperrier@thecenternj.com.